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Activation of human RNase L by 2′- and 5′-O-methylphosphonate-modified oligoadenylates

✍ Scribed by Ondřej Páv; Natalya Panova; Jan Snášel; Eva Zborníková; Ivan Rosenberg


Book ID
113496383
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
530 KB
Volume
22
Category
Article
ISSN
0960-894X

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me 2 A), p5 H (me 2 A)2 H p5 H A2 H p5 H A, and p5 H (me 2 A) 2 H p5 H (me 2 A)2 H p5 H (me 2 A), were prepared via a modi®cation of a lead ion-catalyzed ligation reaction. These 5 H -monophosphates were subsequently converted into the corresponding 5 H -triphosphates. Both binding and activation of