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Activation of human peripheral blood B cells following immunization with hepatitis B surface antigen vaccine

✍ Scribed by Thomas R. Cupps; Paul K. Goldsmith; David J. Volkman; John L. Gerin; Robert H. Purcell; Anthony S. Fauci


Book ID
113133095
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
648 KB
Volume
86
Category
Article
ISSN
0008-8749

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The hepatitis B virus genome encodes a transcriptional transactivator protein designated HBxAg. We have investigated whether this antigen is a target structure for human T-lymphocytes. Using recombinant HBxAg protein, we found HBxAg-specific stimulation of peripheral blood mononuclear cells in patie