Activation of Hedgehog Signaling Inhibits Osteoblast Differentiation of Human Mesenchymal Stem Cells
โ Scribed by Magali Plaisant; Coralie Fontaine; Wendy Cousin; Nathalie Rochet; Christian Dani; Pascal Peraldi
- Book ID
- 111845822
- Publisher
- AlphaMed Press
- Year
- 2009
- Tongue
- English
- Weight
- 915 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1066-5099
No coin nor oath required. For personal study only.
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## Abstract Several biological events are controlled by Hedgehog (Hh) signaling, including osteoblast phenotype development. This study aimed at evaluating the gene expression profile of human mesenchymal stem cells (hMSCs) treated with the Hh agonist, purmorphamine, focusing on Hh signaling and os
Human adult bone marrow-derived skeletal stem cells a.k.a mesenchymal stem cells (hMSCs) have been shown to be precursors of several different cellular lineages, including osteoblast, chondrocyte, myoblast, adipocyte, and fibroblast. Several studies have shown that cooperation between transforming g