The growth of solid neoplasms requires the recruitment of a supporting stroma. In most epithelial cancers, this stromal compartment comprises newly formed blood vessels and abundant, reactive stromal fibroblasts. Tumor stromal fibroblasts are not transformed but differ from resting fibrocytes in nor
Activation of fibroblasts in cancer stroma
✍ Scribed by Kati Räsänen; Antti Vaheri
- Book ID
- 113956015
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 723 KB
- Volume
- 316
- Category
- Article
- ISSN
- 0014-4827
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## Abstract Fibrogenesis, expressed as “desmoplasia,” is found in many kinds of tumors and considered to be associated with malignancy. In fact, fibroblasts in cancer stroma have attracted considerable attention in the last 2 decades. Although it is accepted that fibroblasts are important in tumor
## Abstract Fibroblasts, which are a major component of cancer‐induced stroma, can have a significant impact on the progression of adjacent malignant epithelia. To characterize fibroblasts recruited into cancer‐induced stroma, we examined the recruitment efficiency of 9 human fibroblast cell lines