Pyrrolidine dithiocarbamate (PDTC), a metal chelating compound, is known to induce cell death in vascular smooth muscle cells (VSMC). However, the molecular mechanism for PDTC-induced VSMC death is not well understood. Addition of PDTC reduced cell growth and DNA synthesis on VSMC in low density con
โฆ LIBER โฆ
Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1
โ Scribed by S. Dangi; F. M. Chen; P. Shapiro
- Book ID
- 108677714
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 555 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0960-7722
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## Abstract Abnormalities in cell cycle progression provide unlimited replicative potential to cancer cells, and therefore targeting of key cell cycle regulators could be a sound cancer chemopreventive strategy. Earlier, we found that grape seed extract (GSE) increases Cip/p21 protein level and inh