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Activation of excitatory amino acid receptors reduces thymidine incorporation and cell proliferation rate in primary cultures of astrocytes

✍ Scribed by D.F. Condorelli; F. Ingrao; G. Magri; V. Bruno; F. Nicoletti; R. Avola

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 260 KB
Volume: 2
Category: Article
ISSN: 0894-1491
DOI: 10.1002/glia.440020108

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✦ Synopsis

Addition of quisqualate (a heterocyclic analogue of glutamate) reduced [meth~l-~HIthymidine incorporation and cell proliferation in primary cultures of rat cortical astrocytes. The inhibitory action of quisqualate was mimicked by glutamate and ibotenate, whereas kainate, N-methyl-D-aspartate (NMDA) and mamino-3-hydroxy-5methyl-4-isoxazolepropionate (AMPA) were inactive. These results suggest that activation of a specific class of excitatory amino acid receptors contributes to the regulation of growth and proliferation of glial cells in primary culture.

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