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Activation of ERK1/2 by protein kinase C-α in response to hydrogen peroxide-induced cell death in human gingival fibroblasts

✍ Scribed by Gloria Gutiérrez-Venegas; Juan Antonio Arreguín-Cano; Rita Arroyo-Cruz; Mónica Villeda-Navarro; José Antonio Méndez-Mejía

Book ID: 116920102
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 686 KB
Volume: 24
Category: Article
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2009.08.007

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## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα