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Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

✍ Scribed by Balañá, Maria Eugenia; Labriola, Leticia; Salatino, Mariana; Movsichoff, Federico; Peters, Giselle; Charreau, Eduardo H; Elizalde, Patricia V

Book ID: 110064355
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 422 KB
Volume: 20
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1204050

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## Abstract We examined the relationship between signal transduction and the expression of insulin‐like growth factor I (IGF‐I), IGF‐I receptor level, and IGF binding proteins (IGFBPs) in murine clonal osteoblastic MC3T3‐E1 cells. 12–O‐Tetradecanoylphorbol‐13‐acetate (TPA), an activator of protein