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Activation of EGF-receptor tyrosine kinase (TYR-K) and increased synthesis and secretion of TGF-α in azoxymethane-induced colonic carcinogenesis

✍ Scribed by K. Ponduri; A.P.N. Majumdar


Book ID
118880106
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
171 KB
Volume
108
Category
Article
ISSN
0016-5085

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The epidermal growth factor (EGF) receptor mediates the effects of both EGF and transforming growth factor alpha (TGFalpha). Recent data suggested that EGF acts as a partial agonist/antagonist in hepatocytes, TGFalpha exerting a larger maximal stimulation of DNA synthesis than EGF. To further study