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Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation

โœ Scribed by Akiko Uchida; Seiki Hirano; Hiroyuki Kitao; Atsuko Ogino; Kanmei Rai; Shinichi Toyooka; Nagio Takigawa; Masahiro Tabata; Minoru Takata; Katsuyuki Kiura; Mitsune Tanimoto


Book ID
108583811
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
393 KB
Volume
98
Category
Article
ISSN
1347-9032

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Epidermal growth factor receptor (EGFR)
โœ Sae-Won Han; Pil Gyu Hwang; Doo Hyun Chung; Dong-Wan Kim; Seock-Ah Im; Young Tae ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 351 KB ๐Ÿ‘ 1 views

## Abstract Gefitinib has shown meaningful antitumor activity with tolerable toxicity in chemotherapyโ€refractory NSCLC in previous studies. Moreover, EGFR expression failed to show a correlation with response. In an attempt to identify predictive markers of response, we have investigated the tumora