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Activation of Different Lipoxygenase Isozymes Induces Apoptosis in Human Erythroleukemia and Neuroblastoma Cells

✍ Scribed by Mauro Maccarrone; Marco Ranalli; Lorenza Bellincampi; Maria Luisa Salucci; Stefania Sabatini; Gerry Melino; Alessandro Finazzi-Agrò

Book ID
115585686
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
136 KB
Volume
272
Category
Article
ISSN
0006-291X

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Tiazofurin, an anticancer drug which inhibits IMP dehydrogenase, decreases cellular GTP concentration, induces differentiation and down-regulates ras and myc oncogene expression, caused apoptosis of K562 cells in a time-and dose-dependent fashion. Apoptotic cells were detected by (1) flow cytometry,