Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia
โ Scribed by Prochazkova, Michaela; Terse, Anita; Amin, Niranjana D; Hall, Bradford; Utreras, Elias; Pant, Harish C; Kulkarni, Ashok B
- Book ID
- 121577409
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 480 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1744-8069
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## Abstract Cyclinโdependent kinase 5 (Cdk5)โp35 is downregulated in cultured neurons by __N__โmethylโdโaspartate (NMDA) via the proteasomal degradation of p35. However, it is not known where in neurons this downregulation occurs or the physiologic meaning of the reaction. We show the enrichment of
## Abstract Cyclinโdependent kinase 5 (cdk5), in contrast to other members of the cyclinโdependent kinase family, is not activated by cyclins but instead is activated by complexing with neuronโspecific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and i