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Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia

โœ Scribed by Prochazkova, Michaela; Terse, Anita; Amin, Niranjana D; Hall, Bradford; Utreras, Elias; Pant, Harish C; Kulkarni, Ashok B


Book ID
121577409
Publisher
BioMed Central
Year
2013
Tongue
English
Weight
480 KB
Volume
9
Category
Article
ISSN
1744-8069

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## Abstract Cyclinโ€dependent kinase 5 (cdk5), in contrast to other members of the cyclinโ€dependent kinase family, is not activated by cyclins but instead is activated by complexing with neuronโ€specific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and i