Activation of common fragile sites as a possible cause of chromosome 8 instability in colorectal cancer
✍ Scribed by Lena Brueckner; Manfred Schwab; Larissa Savelyeva
- Book ID
- 113513865
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 32 KB
- Volume
- 203
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Loss of heterozygosity (LOH) on the short arm of chromosome 8 occurs at high frequencies in many tumor types, including colorectal carcinoma. We have previously used microcell‐mediated chromosome transfer (MMCT) to map an approximately 7.7 Mb colorectal cancer suppressor region (CRCSR)
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