Activation of central 5HT1B receptors increases locomotor activity in mice

✍ Scribed by Michael F. O'Neill; Andrés G. Fernández; José M. Palacios

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 120 KB
• Volume: 12
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199709/10)12:5<431::aid-hup884>3.0.co;2-o

✦ Synopsis

The eects of 5-HT1B/D receptor agonists anpirtoline, S-CM-GTNH2 and CP93129 were examined in locomotor activity tests in mice. Anpirtoline and S-CM-GTNH2 both signi®cantly increased locomotor activity (ambulation) (minimum aective doses; 3 and 30 mg/kg respectively). CP 93129 injected subcutaneously was without eect, but increased locomotor activity when given i.c.v. Thus activation of central 5-HT1B receptors results in increased locomotor activity. The eects of anpirtoline and S-CM-GTNH2 were blocked by the antagonist GR 127935 suggesting that GR 127935 is an eective antagonist of 5-HT1B receptors in vivo.