Activation of CD4+CD25+ regulatory T cell suppressor function by analogs of the selecting peptide
✍ Scribed by Joseph Larkin III; Cristina Cozzo Picca; Andrew J. Caton
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 288 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
CD4 ؉ CD25 ؉ regulatory T cells (Treg) are important mediators of peripheral immune tolerance; however, whether Treg participate also in hepatic immune tolerance is not clear. Therefore, we tested the potential of Treg to suppress stimulation of CD4 ؉ T cells by liver sinusoidal endothelial cells (L
## Abstract Both CTLA‐4 and TGF‐β have been implicated in suppression by CD4^+^CD25^+^ regulatory T cells (Treg). In this study, the relationship between CTLA‐4 and TGF‐β in Treg function was examined. Blocking CTLA‐4 on wild‐type Treg abrogated their suppressive activity __in vitro__, whereas neut