Activation of c-Ki-Ras by point mutation in BOP-induced precancerous lesions and adenocarcinoma of Syrian hamster pancreas

Pancreatic ductal adenocarcinomas induce

Pancreatic ductal adenocarcinomas induced in syrian hamsters by N-nitrosobis (2-oxopropyl) amine contain a c-Ki-ras oncogene with a point-mutated codon 12

✍ Hideki Fujii; Hiroshi Egami; William Chaney; Parviz Pour; Jill Pelling 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 552 KB

## Abstract We have used the polymerase chain reaction and dideoxynucleotide sequencing to amplify and sequence exons 1 and 2 of the c‐Ki‐__ras__ proto‐oncogene from the normal Syrian golden hamster. Similar methods were employed to screen for the presence of point mutations in the c‐Ki‐__ras__ onc