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Activation of c-Jun N-terminal kinase 1 (JNK1) in mistletoe lectin II-induced apoptosis of human myeloleukemic U937 cells

✍ Scribed by Raekil Park; Myung-Sunny Kim; Hong-Seob So; Byung-Hak Jung; Sun-Rock Moon; Sang-Young Chung; Chang-Bo Ko; Bok-Ryang Kim; Hun-Taeg Chung


Book ID
113992461
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
387 KB
Volume
60
Category
Article
ISSN
0006-2952

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Human monocytic leukemia U937 cells undergo apoptosis when treated with antitumor drugs, such as etoposide, camptothecin and mitomycin C. The molecular mechanism of the drug-induced apoptosis is not well understood. In this study, we found that 2-deoxyglucose (2DG), an analog of D-glucose and an ind