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Activation of Autoreactive B Cells by CpG dsDNA

✍ Scribed by Gregory A Viglianti; Christina M Lau; Timothy M Hanley; Benjamin A Miko; Mark J Shlomchik; Ann Marshak-Rothstein


Book ID
117723477
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
498 KB
Volume
19
Category
Article
ISSN
1074-7613

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## Abstract Polyclonal activation of developing B cells is an injurious process, because most of these cells are nontolerant and express autoreactive receptors. CpG DNA is a polyclonal activator of mature B cells, but its effect on developing B cells is unclear. We tested whether developing, nontol