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Activation of ATP-sensitive potassium channels by nicorandil is preserved in aged vascular smooth muscle cells in rats

✍ Scribed by Fumimoto Yamazaki, Haidong Chi, Satoru Eguchi, Takashi Kawano


Book ID
120914727
Publisher
Springer
Year
2013
Tongue
English
Weight
195 KB
Volume
27
Category
Article
ISSN
0913-8668

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Modulation of ATP-sensitive potassium ch
✍ C. G. Nichols; E. Niggli; W. J. Lederer πŸ“‚ Article πŸ“… 1990 πŸ› Springer 🌐 English βš– 355 KB

We have used 'caged-ATP' to investigate the kinetic behavior of KATP channels in ventricular cells from rat heart. In whole cells, loaded with 'caged-ATP', an increase of intracellular [ATP] following a UV light flash produced a decrease of KATP channel current that was too slow (tau approximately 3