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Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro

✍ Scribed by A. G. Pokrovskii; A. B. Shintyapina; N. V. Pronkina; V. S. Kozhevnikov; O. A. Plyasunova; E. E. Shul’ts; G. A. Tolstikov

Book ID: 111469712
Publisher: SP MAIK Nauka/Interperiodica
Year: 2006
Tongue: English
Weight: 190 KB
Volume: 407
Category: Article
ISSN: 1607-6729
DOI: 10.1134/s160767290602013x

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## Abstract Betulinic acid (BA), a pentacyclic triterpene of natural origin, effectively induces apoptosis in neuroectodermal tumors and was recently shown to be a potent trigger of cell death in human leukemia‐derived cell lines. To explore the potential of BA in the treatment of hematologic malig