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Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis

✍ Scribed by Sandrine Horman; Gareth J. Browne; Ulrike Krause; Jigna V. Patel; Didier Vertommen; Luc Bertrand; Alain Lavoinne; Louis Hue; Christopher G. Proud; Mark H. Rider

Book ID
114319342
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
202 KB
Volume
12
Category
Article
ISSN
0960-9822

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πŸ“œ SIMILAR VOLUMES

Lopinavir impairs protein synthesis and
Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
✍ Ly Q. Hong-Brown; C. Randell Brown; Danuta S. Huber; Charles H. Lang πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 299 KB

## Abstract HIV anti‐retroviral drugs decrease protein synthesis, although the underlying regulatory mechanisms of this process are not fully established. Therefore, we investigated the effects of the HIV protease inhibitor lopinavir (LPV) on protein metabolism. We also characterized the mechanisms