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Activation of alternative HER receptors mediates resistance to EGFR tyrosine kinase inhibitors in breast cancer cells

✍ Scribed by A. Kong; V. Calleja; P. Leboucher; A. Harris; P. Parker; B. Larijani


Book ID
119598441
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
85 KB
Volume
6
Category
Article
ISSN
1359-6349

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## Abstract We investigated the role of the MEK/MAPK pathway in the sensitivity/resistance of breast carcinoma cells to the EGFR tyrosine kinase inhibitor gefitinib (IRESSA). We assessed the effects of gefitinib on the growth of three breast cancer cell lines that showed high (SK‐Br‐3; IC~50~ 4 Β΅M)