## Abstract Signal transducers and activators of transcription (STATs) are a family of transcription factors that are of central importance for cellular signaling and have therefore emerged as attractive target proteins for cell‐permeable small molecules. This review outlines the basic concept of S
✦ LIBER ✦
Activation Instead of Inhibition: Targeting Proenzymes for Small-Molecule Intervention
✍ Scribed by Christian Ottmann; Patrick Hauske; Markus Kaiser
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 363 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1439-4227
No coin nor oath required. For personal study only.
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## Abstract The Flt3 receptor tyrosine kinase is a critical mediator in the pathogenesis of acute myeloid leukaemia (AML). Flt3‐activating mutations have been associated with poor prognosis and decreased overall survival of AML patients, thus Flt3 constitutes an ideal target for drug treatment of s