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Activation-induced cytidine deaminase structure and functions: A species comparative view

✍ Scribed by Vasco M. Barreto; Brad G. Magor

Book ID
116401956
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
871 KB
Volume
35
Category
Article
ISSN
0145-305X

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Activation-induced cytidine deaminase (AID; gene symbol AICDA) is the key molecule required to induce immunoglobulin (Ig) class switch recombination (CSR) and somatic hypermutation (SHM) of the variable regions of Ig genes. Its deficiency causes a form of hyper-IgM (HIGM) syndrome. The study of natu