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Activation for Catalysis of Penicillin-Binding Protein 2a from Methicillin-Resistant Staphylococcus a ureus by Bacterial Cell Wall

✍ Scribed by Fuda, Cosimo; Hesek, Dusan; Lee, Mijoon; Morio, Ken-ichiro; Nowak, Thomas; Mobashery, Shahriar


Book ID
127197829
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
46 KB
Volume
127
Category
Article
ISSN
0002-7863

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Penicillin-binding protein 2a (PBP2a), a high molecular mass PBP, is the primary enzyme responsible for the b-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA). Inhibition of a PBP such as PBP2a by b-lactams is due to covalent modiÐcation of an active site serine residue. Based