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Activation and expansion of tumour-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies

✍ Scribed by Erik W. P. Nijhuis; Elly v/d Wiel-van Kemenade; Carl G. Figdor; René A. W. van Lier

Publisher
Springer-Verlag
Year
1990
Tongue
English
Weight
733 KB
Volume
32
Category
Article
ISSN
0340-7004

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A tumor vaccine containing anti-CD3 and anti-CD28 bispecific antibodies triggers strong and durable antitumor activity in human lymphocytes
✍ Claudia Haas; Maria Lulei; Philippe Fournier; Annette Arnold; Volker Schirrmache 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 636 KB

## Abstract We recently reported on newly designed virus‐targeted bispecific CD3‐ and CD28‐binding molecules for human T‐cell activation. When bound via one arm to a human virus‐modified tumor cell vaccine, these reagents caused a polyclonal T‐cell response and overcame the potential various T‐cell