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Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction

✍ Scribed by Gerard Bain; Thomas Müller; Xin Wang; Jackie Papkoff

Book ID
117053149
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
319 KB
Volume
301
Category
Article
ISSN
0006-291X

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The molecular mechanisms by which bone morphogenetic proteins (BMPs) promote skeletal cell differentiation were investigated in the murine mesenchymal stem cell line C3H10T1/2. Both BMP-7 and BMP-2 induced C3H10T1/2 cells to undergo a sequential pattern of chondrogenic followed by osteogenic differe