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Activated T lymphocytes in infiltrates and draining lymph nodes of nasopharyngeal carcinoma

✍ Scribed by Dr. Uri Galili; Eva Klein; George Klein; Inderjit Singh Bal

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
422 KB
Volume
25
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Lymphocytes isolated from the tumors and draining lymph nodes of nasopharyngeal carcinoma (NPC) patients exhibit the following characteristics of immune activation: (1) stable E rosette formation, (2) natural attachment to various human cells, (3) sensitivity in vitro to the lytic effect of glucocorticoids. Although the NPC T cells attach in vitroto various cells they kill only EBV‐genome‐carrying targets. These findings suggest the occurrence of a local cellular immune response in NPC, possibly directed to EBV‐determined antigens.

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