Phencyclidine (PCP) is a drug of abuse that produces schizophrenia-like symptoms in humans and increases locomotor activity and stereotypic behavior in rodents. PCP-induced alteration in rat locomotor activity is thought to be mediated by an inhibition of N-methyl-D-aspartate (NMDA) receptors in the
✦ LIBER ✦
Activated microglial supernatant induced motor neuron cytotoxicity is associated with upregulation of the TNFR1 receptor
✍ Scribed by Weiyan Wen; Teresa Sanelli; Weiwen Ge; Wendy Strong; Michael J. Strong
- Book ID
- 116774757
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 261 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0168-0102
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## Abstract The anti‐neoplastic effects of 1,25‐dihydroxyvitamin D~3~ (1,25D) are well documented in numerous tumor cell systems and animal models of cancer. However, despite this pre‐clinical success, the clinical use of 1,25D is currently impeded by the dose‐limiting hypercalcemia, and the risk o