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Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

✍ Scribed by O'Rourke, Anne M.; Rogers, Joy; Mescher, Matthew F.


Book ID
109764191
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
394 KB
Volume
346
Category
Article
ISSN
0028-0836

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Although the role of CD8 as a supplier of lck is unchallenged, its role in contributing to the formation of a stable complex between class I molecules and the TCR, as well as its role as an adhesion molecule, is less clear. To address the role of CD8/MHC-I interactions, we generated tetramers compos