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Activated carbon beads for the removal of highly albumin-bound species

✍ Scribed by Naomi I. Nakano; Yoshimitsu Shimamori; Masahiro Nakano

Publisher: Elsevier Science
Year: 1983
Tongue: English
Weight: 636 KB
Volume: 129
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(83)90053-2

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✦ Synopsis

Activated carbon beads in which 5% activated carbon powder was embedded in 4% agarose were prepared by the emulsion technique. The column of the beads was demonstrated to effectively remove salicylic acid, warfarin, and long-chain fatty acids from solutions containing albumins by either zonal or frontal analysis under the condition of 0.1 M NaCl, pH 3.0 (HCl). The beads were also demonstrated to purify a commercial human serum albumin preparation from residual fattv acids. The beads would be of value in many biochemical purification processes in which activated carbon is employed.

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