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Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice

✍ Scribed by Nicole Stupka; David R. Plant; Jonathan D. Schertzer; Tennent M. Emerson; Rhonda Bassel-Duby; Eric N. Olson; Gordon S. Lynch

Book ID: 110113938
Publisher: Cambridge University Press
Year: 2006
Tongue: English
Weight: 559 KB
Volume: 575
Category: Article
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2006.108472

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Absence of dystrophin in mdx muscles may render the muscle more susceptible to damage when submitted to high stress levels. To test this, typically slow (soleus) and fast (EDL) limb muscles of dystrophic (mdx) and normal (C57BL/10) mice were submitted (in vitro) to a series of isometric contractions