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Activated Akt expression in breast cancer — relationships to p53, Mdm2 and patient outcome

✍ Scribed by S Vestey; C Sen; C Calder; Z.E Winters


Book ID
118622136
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
163 KB
Volume
2
Category
Article
ISSN
1359-6349

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p53 allele losses, mutations and express
✍ A. M. Thompson; T. J. Anderson; A. Condie; J. Prosser; U. Chetty; D. C. Carter; 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 761 KB

The p53 locus on the short arm of chromosome I 7 at I7p 13. I was examined for loss of heterozygosity, mutation, rnRNA and protein expression in 60 primary breast cancers. Allele loss around the p53 locus was detected in 19/45 informative turnours (42%). p53 mutations in the evolutionarily conserved