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Actions of α2 adrenoceptor ligands at α2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for α2A adrenoceptors

✍ Scribed by A. Newman-Tancredi; J.-P. Nicolas; V. Audinot; S. Gavaudan; L. Verrièle; M. Touzard; C. Chaput; N. Richard; M. J. Millan


Publisher
Springer-Verlag
Year
1998
Tongue
English
Weight
145 KB
Volume
358
Category
Article
ISSN
0028-1298

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Herein, we evaluate the interaction of the ␣ 2 -AR antagonist, yohimbine, as compared to fluparoxan, at multiple monoaminergic receptors and examine their roles in the modulation of adrenergic, dopaminergic and serotonergic transmission in freelymoving rats. Yohimbine displays marked affinity at hum