Actions of Kavain and Dihydromethysticin on Ipsapirone-Induced Field Potential Changes in the Hippocampus
✍ Scribed by JÖRG WALDEN; JÖRG VON WEGERER; UTE WINTER; M. BERGER
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 136 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
The kava-pyrones kavain and dihydromethysticin are constituents of Piper methysticum which possess muscle relaxant, anticonvulsant, analgesic and anxiolytic properties. In the present study the eect of both kava-pyrones were tested on ®eld potential changes induced by the serotonin-1A agonist ipsapirone in the area CA1 and CA3 of the hippocampal slice preparation of guinea pigs. Ipsapirone induced positive ®eld potential changes which were decreased in amplitude by the serotonin-1A antagonist NAN. The ipsapirone response was reduced by extracellular administration of kavain and dihydromethysticin in a dose-dependent manner down to 22 . 2 and 33 . 6%, respectively. It is suggested that kavain and dihydromethysticin modulate serotonin-1A receptor activity which may be of importance in the anti-anxiety action of kava-pyrones.