Actions of acromelic acid on nervous system l-glutamate receptors
✍ Scribed by David B. Sattelle; Maria-Isabel Sepúlveda; Haruhiko Shinozaki; Michiko Ishida
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 413 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0739-4462
No coin nor oath required. For personal study only.
✦ Synopsis
Acromelic acid, a naturally occurring kainoid, isolated from the mushroom Clitocybe acromelalga, is a weak displacer of [3H]L-glutamate binding to cockroach (feriplaneta americana) nerve cord membranes. Acromelic acid (1 mM) displaces -60% of specifically bound [3H]L-glutarnate. When applied by bath perfusion to the cell body membrane of the cockroach fast coxal depressor motor neurone, acromelic acid generated slow, prolonged, dose-dependent depolarizations at concentrations of 0.3 pM and above. Thus acromelic acid is among the most potent of the excitatory amino acids tested to date on insect neurones. o 1994 WiIey-Liss, Inc.