Action of some drugs on the “one-footed position test” in the pigeon

✍ Scribed by G. Benzi; A. Crema; G. M. Frigo

• Publisher: John Wiley and Sons
• Year: 1965
• Tongue: English
• Weight: 187 KB
• Volume: 54
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600541134

✦ Synopsis

The potencies of various anti-inflammatory drugs are evaluated in the pigeon by means of a simple functional test. Indomethacin is more active than dexamethasone, contrary to the results obtained by other anti-inflammatory tests. The activity of the drugs seems unrelated to the antinociceptive properties. Histamine, but not , serotonin, seems to be involved in the production of the local injury.

T IS common knowledge that in the series of events I occurring in inflammation there are dilatation and increase in blood vessel permeability, leucocytic emigration, fluid accumulation, cellular proliferation, etc., with functional changes of the injured tissues.

A simultaneous evaluation of all the above mentioned modifications is not possible by using the routine methods of testing for anti-inflammatory activity.