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Action of Pluchea indica methanol extract as a dual inhibitor on PAF-induced paw oedema and gastric damage

✍ Scribed by T. Sen; T. K. Ghosh; S. Bhattacharjee; A. K. Nag Chaudhuri

Book ID: 101285466
Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 295 KB
Volume: 10
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199602)10:1<74::aid-ptr763>3.0.co;2-w

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✦ Synopsis

The effect of the methanol fraction of Plucheu indicu (P. indku) and certain standard drugs were evaluated on platelet activation factor (PAF)-induced inflammation, gastric necrosis, ulceration and haematological picture. Administration of PAF (i.v.) for 20 min produced significant alteration in haematological profiles, considerable inflammation, severe gastric mucosal vasocongestion, necrosis and ulceration. Pretreatment with either P. indicu and certain standard drugs significantly inhibited inflammation and incidences of lowered gastric damage.