Action of antibiotics on respiratory tract I: Ampicillin

✍ Scribed by G. Benzi; E. Bermudez; E. Arrigoni

• Book ID: 102400382
• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 375 KB
• Volume: 59
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600590426

✦ Synopsis

In uitro ampicillin antagonizes the barium chloride-, histamine-, and acetylcholine-induced spasm on the dog bronchial chains. Ampicillin is more effective in preventing a histamine than an acetylcholine bronchospasm, while isoprenaline and adrenaline are similarly potent against the effects of the two agonists. In situ the antibiotic induces at first a prompt but short increase in ventilation; subsequently, a lesser but persistent activity remains for 2 or 3 hr.

Keyphrases

Ampicillin effect-respiratory tract 0 Histamine-, barium chloride-, acetylcholine-induced bronchospasm-ampicillin effect 0 Respiratory ventilation-ampicillin effect