The influence of mepiprazole (EMD 16,923), a new pyrazol-ylalkyl-piperazine derivative, on the uptake of 3H-norepinephrine (NE), 3H-dopamine (DA), and 3H-serotonin (5-HT) into rat brain synaptosomes from cerebral cortex, corpus striatum, and hypothalamus was investigated in comparison with several p
โฆ LIBER โฆ
Action of a new psychotropic drug (Sulpiride) on avoidance behavior in rats
โ Scribed by O. Fontaine; Ph. Libon; M. Richelle
- Publisher
- Springer
- Year
- 1974
- Tongue
- English
- Weight
- 246 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0033-3158
No coin nor oath required. For personal study only.
โฆ Synopsis
Sulpiride, a new psychotropic drug with neuroleptic activity, was administered to rats in a Sidman avoidance schedule. Doses ranging from 1 to 80 mg/kg resulted in the animal receiving fewer shocks. This effect was not correlated with an increase of responding and seemed unrelated to the suppressing action abruptly observed at high doses (i. e. 150 to 200 mg/kg). These results differ from those classiealy obtained with other neuroleptics.
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