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Actinomycin D toxicity in the treatment of trophoblastic disease: A comparison of the five-day course to single-dose administration

✍ Scribed by Edmund S. Petrilli; C.Paul Morrow

Book ID: 119051899
Publisher: Elsevier Science
Year: 1980
Tongue: English
Weight: 255 KB
Volume: 9
Category: Article
ISSN: 0090-8258
DOI: 10.1016/0090-8258(80)90004-9

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✦ Synopsis

Toxicity following actinomycin D delivered in divided doses over 5 days was compared to that following single-dose administration in 18 patients with nonmetastatic trophoblastic disease. Analysis revealed a predominance of hematologic effects following single-dose therapy, while hematologic and nonhematologic toxicity was evenly distributed after divided-dose administration. Although total toxicity was greater with single-dose administration, it was primarily due to mild adverse effects, while severe toxicity was similar in both groups. The toxicity of single-dose administration appears to be acceptable, but comparisons of efficacy must await further study.

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