The nuclear isoform of myosin, Nuclear Myosin I (NMI) is involved in transcription by RNA polymerase I. Previous experiments showing that antibodies to NMI inhibit transcription by RNA polymerase II using HeLa cell nuclear extract (NE) suggested that NMI might be a general transcription factor for R
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Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
β Scribed by Hofmann, Wilma A.; Stojiljkovic, Ljuba; Fuchsova, Beata; Vargas, Gabriela M.; Mavrommatis, Evangelos; Philimonenko, Vlada; Kysela, Katarina; Goodrich, James A.; Lessard, James L.; Hope, Thomas J.
- Book ID
- 109912288
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 703 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1465-7392
- DOI
- 10.1038/ncb1182
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Cdc2 kinase triggers the entry of mammalian cells into mitosis, the only cell cycle phase in which transcription is globally repressed. We show here that Cdc2 kinase phosphorylates components of the RNA polymerase II transcription machinery including the RNA polymerase II carboxy-terminal repeat dom