Insulin has diverse effects on cells, including stimulation of glucose transport, gene expression, and alterations of cell morphology. The hormone mediates these effects by activation of signaling pathways which utilize, 1) adaptor molecules such as the insulin receptor substrates (IRS), the Src and
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy
β Scribed by Cingolani, Lorenzo A.; Goda, Yukiko
- Book ID
- 109962683
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 128 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1471-0048
- DOI
- 10.1038/nrn2410
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The actin cytoskeleton mediates a variety of essential biological functions in cells, including division, shape changes, and movement. A number of studies have suggested that the abundant submembranous actin cytoskeleton present in the cortex of many cell types is involved in the regulation of cell
The dendritic spine may be considered a fusion of a specialized actin-based structure akin to filopodia and lamellopodia, with an excitatory postsynaptic density containing glutamate receptors and signal-transducing machinery. This specialized neuronal microdomain is the site of the majority of exci