## Abstract **Background:** Cofilin, a key regulator of actin filament dynamics, is inactivated by phosphorylation at Serβ3 by LIMβkinases and is reactivated by dephosphorylation by a family of protein phosphatases, termed Slingshot (SSH). **Results:** We have identified two novel isoforms of SSHs
β¦ LIBER β¦
Actin filaments-stabilizing and -bundling activities of cofilin-phosphatase Slingshot-1
β Scribed by Souichi Kurita; Emi Gunji; Kazumasa Ohashi; Kensaku Mizuno
- Book ID
- 108731937
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 407 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1356-9597
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Cofilin, an actin-depolymerizing protein, is essential for the functional dynamics of the actin cytoskeleton and for cell viability. In unstimulated human peripheral blood T lymphocytes cofilin is phosphorylated and localized in the cytoplasm. Following co-stimulation through accessory receptors (e.