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Actin filament formation, reorganization and migration are impaired in hepatic stellate cells under influence of trichostatin A, a histone deacetylase inhibitor

✍ Scribed by Krista Rombouts; Thomas Knittel; Laura Machesky; Filip Braet; Annemie Wielant; Karine Hellemans; Pieter De Bleser; Irwin Gelman; Giuliano Ramadori; Albert Geerts

Book ID: 118564787
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 537 KB
Volume: 37
Category: Article
ISSN: 0168-8278
DOI: 10.1016/s0168-8278(02)00275-1

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Hepatic stellate cells are the major cellular sources of extracellular matrix in chronic liver diseases leading to fibrosis. We explored the antifibrogenic effect of two histone deacetylase inhibitors, sodium butyrate and trichostatin A (TSA), on this cell type in vitro. Primary hepatic stellate cel