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Actin-dependent clustering of insulin receptors in membrane microdomains

โœ Scribed by Peter W. Winter; Alan K. Van Orden; Deborah A. Roess; B. George Barisas

Book ID
116275252
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
495 KB
Volume
1818
Category
Article
ISSN
0005-2736

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High-affinity binding of insulin to receptors in human erythrocyte membranes occurred at the external surface, but not at the cytoplasmic surface of the plasma membrane, as assessed by insulin binding to right-side-out and inside-out membrane vesicles. Even after prolonged (3 h) incubation at 22"C,