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Actin Bundle Stabilization During Cell Spreading on Micropatterned Substrates

✍ Scribed by Meister, Jean-Jacques; Smith-Clerc, Josiane; Vianay, Benoît


Book ID
122094483
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
59 KB
Volume
106
Category
Article
ISSN
0006-3495

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HeLa cell spreading on a gelatin substrate requires the activation of protein kinase C (PKC), which occurs as a result of cell-attachment-induced activation of phospholipase A2 (PLA2) to produce arachidonic acid (AA) and metabolism of AA by lipoxyginase (LOX). The present study examines how PKC acti