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Acrylonitrile solubility in human blood: Determination of the Ostwald partition coefficient

✍ Scribed by L. Cheng; R. Jaeger

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 275 KB
Volume: 2
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550020105

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✦ Synopsis

Abstract

An in vitro head space method was used to determine the Ostwald partition coefficient (OPC) of acrylonitrile in the following liquids: lactated Ringer's solution, fresh rat blood, fresh human blood, outdated human blood and cellular fractions of either fresh or outdated human blood. Fresh human blood cells have the strongest affinity for acrylonitrile (OPC >700). Fresh whole human blood has a lower OPC, approximately 500. Lactated Ringer's solution, outdated human blood and water had lower OPC values, approximately 200.

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