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Acquisition of tolerance to the antiproliferative activity of interferon by X-ray transformed C3H/10T1/2 cells under prolonged treatment with interferon

✍ Scribed by Danièle Brouty-Boyé

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
276 KB
Volume
30
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

X‐ray‐transformed C3H/10T1/2 cells serially passaged in the presence of highly purified mouse interferon appeared to acquire progressively a tolerance to the inhibitory effect of interferon on cell proliferation. In contrast, these cells did not appear to develop a tolerance to the antiviral activity of interferon. These results suggest the possibility that these two effects of interferon are mediated by different mechanisms.

📜 SIMILAR VOLUMES

Decreased sensitivity to interferon asso
Decreased sensitivity to interferon associated with in vitro transformation of X-ray-transformed C3H/10T1/2 cells
✍ Danièle Brouty-Boyé; Ion Gresser; Claire Baldwin 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 356 KB

## Abstract We have compared the interferon sensitivity of parental 10T1/2 cells, having a phenotype characteristic of normal cells, with that of transformed cells isolated after X‐irradiation or treatment with methylcholanthrene. Transformed cells were 10‐ to 20‐fold less sensitive than the parent