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Acquisition of cocaine self-administration in male Sprague–Dawley rats: effects of cocaine dose but not initial locomotor response to cocaine

✍ Scribed by Bruce H. Mandt; Nickie L. Johnston; Nancy R. Zahniser; Richard M. Allen


Publisher
Springer
Year
2011
Tongue
English
Weight
207 KB
Volume
219
Category
Article
ISSN
0033-3158

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Intravenous cocaine self-administration behavior in rats was investigated using a progressive ratio (PR) schedule of reinforcement. The first response on the lever each day produced a drug infusion, whereupon the requirements of the schedule escalated with each reinforcement until the behavior extin